Structure of PDB 5eel Chain E Binding Site BS01
Receptor Information
>5eel Chain E (length=102) Species:
9606
(Homo sapiens) [
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QLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVK
HYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCT
RV
Ligand information
>5eel Chain N (length=9) Species:
32630
(synthetic construct) [
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SFEGYDNSg
Receptor-Ligand Complex Structure
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PDB
5eel
Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Resolution
2.47 Å
Binding residue
(original residue number in PDB)
H433 I436 E440 R529 V530
Binding residue
(residue number reindexed from 1)
H5 I8 E12 R101 V102
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5eel
,
PDBe:5eel
,
PDBj:5eel
PDBsum
5eel
PubMed
27257138
UniProt
Q14451
|GRB7_HUMAN Growth factor receptor-bound protein 7 (Gene Name=GRB7)
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