Structure of PDB 5cxk Chain E Binding Site BS01

Receptor Information

>5cxk Chain E (length=222) Species: 666 (Vibrio cholerae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MPEIKQLFENNSKWSASIKAETPEYFAKLAKGQNPDFLWIGCADSRVPAE
RLTGLYSGELFVHRNVANQVIHTDLNCLSVVQYAVDVLQVKHIIVCGHYG
CGGVTAAIDNPQLGLINNWLLHIRDYYLKHREYLDKMPAEDRSDKLAEIN
VAEQVYNLANSTVLQNAWERGQAVEVHGFVYGIEDGRLEYLGVRCASRSA
VEDNYHKALEKILNPNHRLLCR

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5cxk Chain E Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5cxk Crystal structure and kinetic studies of a tetrameric type II beta-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	C42 D44 H98 C101
Binding residue (residue number reindexed from 1)	C42 D44 H98 C101
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	C42 D44 R46 H98 C101
Catalytic site (residue number reindexed from 1)	C42 D44 R46 H98 C101
Enzyme Commision number	4.2.1.1: carbonic anhydrase.

Gene Ontology

	Molecular Function
GO:0004089	carbonate dehydratase activity
GO:0008270	zinc ion binding
GO:0016829	lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0015976	carbon utilization

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Molecular Function

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Biological Process

External links

PDB	RCSB:5cxk, PDBe:5cxk, PDBj:5cxk
PDBsum	5cxk
PubMed	26627652
UniProt	A0A086SLX8

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