Structure of PDB 5bkj Chain E Binding Site BS01

Receptor Information
>5bkj Chain E (length=317) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATRILLLVLAVIIYGTAGFHFIEGESWTVSLYWTFVTIATVGYGDYSPST
PLGMYFTVTLIVLGIGTFAVAVERLLEFLINREQMKLMGLIDVAKSRHVV
ICGWSESTLECLRELRGSEVFVLAEDENVRKKVLRSGANFVHGDPTRVSD
LEKANVRGARAVIVDLESDSETIHCILGIRKIDESVRIIAEAERYENIEQ
LRMAGADQVISPFVISGRLMSRSIDDGYEAMFVQDVLAEESTRRMVEVPI
PEGSKLEGVSVLDADIHDVTGVIIIGVGRGDELIIDPPRDYSFRAGDIIL
GIGKPEEIERLKNYISA
Ligand information
Ligand IDYQ1
InChIInChI=1S/C20H44N/c1-5-9-13-17-21(18-14-10-6-2,19-15-11-7-3)20-16-12-8-4/h5-20H2,1-4H3
InChIKeyBTVOGRXNCYUFMB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CCCCC[N](CCCCC)(CCCCC)CCCCC
FormulaC20 H44 N
Name1-(tripentyl-$l^{4}-azanyl)pentane
ChEMBL
DrugBank
ZINC
PDB chain5bkj Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5bkj Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		A58 I84
Binding residue
(residue number reindexed from 1)		A39 I65
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5bkj, PDBe:5bkj, PDBj:5bkj
PDBsum5bkj
PubMed37653172
UniProtO27564|MTHK_METTH Calcium-gated potassium channel MthK (Gene Name=mthK)

[Back to BioLiP]