Structure of PDB 5anb Chain E Binding Site BS01

Receptor Information

>5anb Chain E (length=136) Species: 44689 (Dictyostelium discoideum)

MSKAQAVGSNYRVSLGLPVGAVMNSADNSGAKNLYVIAVKGIKGRLNRLP
SAGVGDMVMATVKKGKPELRKKVCTGLVVRQRKHWKRKDGVYIYFEDNAG
VMCNPKGEVKGNILGPVAKECSDLWPKVATNAGTIV

Ligand information

>5anb Chain N (length=1162)

auuagcaguuucgggggcguaaugcucucagcugauucucaaacucugaa
cauuuuugguaagcagaacuggcgauguggguugaaccaaauauugggau
aagacgucuaacauucacuaauagauaccacaaaagguguuaguucauua
agacagcaggacgguggccauggaagucgguauccgcuaaggagugugua
acaacucaccugccaaauggacuagcccugaaaauggaugacgcuagcag
uggauggucgaugcccaaucguuaaaagaagugauaauacuuuuaacaau
ccaacuguuuaauuaaaacaaagcauugcgauaagcuuaaaagcuuuuga
cgcaaugugauuucugcccagugcucugaaugucaaagugaagagauuca
accuagcacggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaucaaugagauu
cccacugucccuaacuacuauacagcgaaaccacugcaaggggaacgggc
cuugcaaaaacagcggggaaagaagacccuguugagcuugacucuagucu
gauauuaacaguuucagguggggaguuuggcuggggcggcacauuuguua
aaagauaacgcaaguguccaaaggcaggcucagugagaacagaaaucuca
cguagaguaaaagggcaaaagccugcuugauucugauuuucaguacuaau
cggaacugggaaaccagggccuaucgauccuuuaugugcuuaaaucuuaa
cccuagaggugucagaaaaguuaccacagggauaacuggcuuguggcagc
caagcgcucauagcgacgcugcuuuuugauccuucgaugucggcucuucu
uaucauugugaagcagaauucacaaaguguuggauuguucacccacuaac
aaggaacgugagcuggguuuagaccgucgugagacagguuaguuuuaccc
uacuguugucaauuguuugcguaauaguagcaugauuuaguacgagagga
acugucaugccggaucacuggucuguagguuuauuugacaaaauagugac
cugccgcuaccauccguuggauaauggcugaacgccucuaagucagaauc
cauucuagaaac

.....<<<<...<<<<<<.....>>>>>>.>>>>................
<<.<<<<<.....>>>>>.>>......<<<......>>>...<<<<<<..
..<<<(((...<<<<<<<.....<..........<<<.<<<<<<<<<<..
.....<<<<<.<<<..<<<.........>>>..>>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>.....>
>>>>>>>>>....>>>>>>.<<<<<<<<...........>>>>>>>><<<
<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>.....
.>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>
.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
....................................<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<.<<.....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<..
.........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>
>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>
>>>>>.<<<....>>>.>>)))......<<<<<<...<.<<.......>>
.>.>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<
...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<
<..<<<<<<<<<......>>>>>>..>>>.<<<.<.....>.>>>.....
>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>
>.>>>>>.............<<..<<<..<<<<<<<..............
...>>>>>>><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>
>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>
>>..>>>...>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5anb Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): A4 S9 Y11 R12 I37 K40 G41 K43 R45 L46 N47 R48 L49 M59 K71 K72 V73 H84 K86 K88 Y92
• Binding residue (residue number reindexed from 1): A4 S9 Y11 R12 I37 K40 G41 K43 R45 L46 N47 R48 L49 M59 K71 K72 V73 H84 K86 K88 Y92

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0031012 extracellular matrix
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5anb, PDBe:5anb, PDBj:5anb
• PDBsum: 5anb
• PubMed: 26479198
• UniProt: Q54G86|RL23_DICDI Large ribosomal subunit protein uL14 (Gene Name=rpl23)