Structure of PDB 4zg4 Chain E Binding Site BS01

Receptor Information
>4zg4 Chain E (length=711) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAVAELYTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLELDYSVNP
ESLPPLRNPDILVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGII
LVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRN
QSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLASNPITEAV
GNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENE
RNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMV
ETQKTFTLLGFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSH
LKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKK
IYAHLFDFIVERINQALQFSGKQHTFIGVLDIYGFETFDVNSFEQFCINY
ANEKLQQQFNMHVFKLEQEEYMKEDIWTLIDFYDNQPVIDLIEAKMGILE
LLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKV
EYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENRTTVGSKFRSSL
YLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRIS
AQSYPWTYIEFYSRYGILKQELSFVCKVVLHRLIQDSNQYQFGKTKIFFR
AVAYLEKLRLD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4zg4 Chain E Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zg4 Force-producing ADP state of myosin bound to actin.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		T168 S216
Binding residue
(residue number reindexed from 1)		T164 S212
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S163 T168 S215 S216
Catalytic site (residue number reindexed from 1) S159 T164 S211 S212
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4zg4, PDBe:4zg4, PDBj:4zg4
PDBsum4zg4
PubMed26976594
UniProtQ9NQX4|MYO5C_HUMAN Unconventional myosin-Vc (Gene Name=MYO5C)

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