Structure of PDB 4z8l Chain E Binding Site BS01

Receptor Information
>4z8l Chain E (length=79) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAPEGAGEVGLEQWLETSLERINREARLHFHPEFLFRLWNTCVEHWHDRH
QRSLDYAKYRYLLLMHKAMYTHMQQGCPC
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4z8l Chain E Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4z8l Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile alpha Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H38 H81 C86
Binding residue
(residue number reindexed from 1)		H29 H72 C77
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0019058 viral life cycle
GO:0046718 symbiont entry into host cell
GO:0075732 viral penetration into host nucleus
Cellular Component
GO:0042025 host cell nucleus
GO:0043657 host cell
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z8l, PDBe:4z8l, PDBj:4z8l
PDBsum4z8l
PubMed26045556
UniProtQ7ZB17

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