Structure of PDB 4z1m Chain E Binding Site BS01

Receptor Information
>4z1m Chain E (length=470) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGEST
VRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGP
IKTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGG
AGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVIN
LKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDN
IFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSV
QAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRI
MDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRA
RKIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAF
YMVGPIEEAVAKADKLAEEH
Ligand information
>4z1m Chain J (length=22) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EEERYFRARAAEQLAALKKHHE
Receptor-Ligand Complex Structure
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PDB4z1m How release of phosphate from mammalian F1-ATPase generates a rotary substep.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		I388 M393 K401 V404 S405 R408 D450 H451 L452 P453 Q455 A474 H477
Binding residue
(residue number reindexed from 1)		I381 M386 K394 V397 S398 R401 D443 H444 L445 P446 Q448 A467 H470
Enzymatic activity
Catalytic site (original residue number in PDB) K162 E188 R189 R356
Catalytic site (residue number reindexed from 1) K155 E181 R182 R349
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z1m, PDBe:4z1m, PDBj:4z1m
PDBsum4z1m
PubMed25918412
UniProtP00829|ATPB_BOVIN ATP synthase subunit beta, mitochondrial (Gene Name=ATP5F1B)

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