Structure of PDB 4yig Chain E Binding Site BS01

Receptor Information
>4yig Chain E (length=220) Species: 10249 (Vaccinia virus Copenhagen) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPMNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDK
FFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISR
LTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHI
TKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEII
NVLLELDNKVPINWAQGFIY
Ligand information
Receptor-Ligand Complex Structure
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PDB4yig Crystal Structure of the Vaccinia Virus Uracil-DNA Glycosylase in Complex with DNA.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D68 P69 Y70 P71 K87 S88 G159 K160 T161 Y180 H181 R185
Binding residue
(residue number reindexed from 1)		D70 P71 Y72 P73 K89 S90 G161 K162 T163 Y182 H183 R187
Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0006281 DNA repair
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4yig, PDBe:4yig, PDBj:4yig
PDBsum4yig
PubMed26045555
UniProtP20536|UNG_VACCC Uracil-DNA glycosylase (Gene Name=OPG116)

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