Structure of PDB 4xst Chain E Binding Site BS01

Receptor Information
>4xst Chain E (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDECG
DICPNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH
HKHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
Ligand information
>4xst Chain F (length=16) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ESSFRKTFEDYLHNVV
Receptor-Ligand Complex Structure
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PDB4xst Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N15 L36 F64 F88 F89 V94 F96 R118 E120
Binding residue
(residue number reindexed from 1)		N11 L32 F60 F84 F85 V90 F92 R114 E116
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:4xst, PDBe:4xst, PDBj:4xst
PDBsum4xst
PubMed26027733
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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