Structure of PDB 4s3o Chain E Binding Site BS01

Receptor Information
>4s3o Chain E (length=99) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQPLSKTWELSLYELQRTPQEAVSPRSLHSELMCPICLDMLKNTMTTKEC
LHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4s3o Chain E Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4s3o BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C51 C54 C72 C75
Binding residue
(residue number reindexed from 1)		C34 C37 C55 C58
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Cellular Component
GO:0000151 ubiquitin ligase complex

View graph for
Cellular Component
External links
PDB RCSB:4s3o, PDBe:4s3o, PDBj:4s3o
PDBsum4s3o
PubMed26151332
UniProtQ99496|RING2_HUMAN E3 ubiquitin-protein ligase RING2 (Gene Name=RNF2)

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