Structure of PDB 4r89 Chain E Binding Site BS01

Receptor Information
>4r89 Chain E (length=537) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVRM
VMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLLK
KDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYEL
RCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLRA
DVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQFA
QHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREASC
APESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPCS
VEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFHS
APADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFVY
WELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQR
RYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4r89 Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
Resolution4.002 Å
Binding residue
(original residue number in PDB)		W184 Y221 R228 R257 K260 Q264 N387 A419 H422 R502 A503 G504 D507 E522 K524 G527 D528 Q531
Binding residue
(residue number reindexed from 1)		W168 Y205 R212 R241 K244 Q248 N371 A403 H406 R486 A487 G488 D491 E506 K508 G511 D512 Q515
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4r89, PDBe:4r89, PDBj:4r89
PDBsum4r89
PubMed25319828
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

[Back to BioLiP]