Structure of PDB 4qqw Chain E Binding Site BS01

Receptor Information
>4qqw Chain E (length=897) Species: 269800 (Thermobifida fusca YX) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYLSPGLRDTIAS
SMETDEEHAGHCIAFWAGLHDIGKLTREFQQQIAIDLSAYPGEELSGEQR
SHAAATGKWLPFALPSLGYPNGGLVTGLVAQMLGGHHGTFHPHPSFQSRN
PLAEFGFSSPHWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL
ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPSLLDAAGLRPI
TVPPATFTESFPHKPNGLQASLAKHLPCLCTGPGLVLITAPMGEGKTEAA
YHVADLLGKATGRPGRFLALPTMATADQMHTRLKEYARYRVENTRSSTLA
LLHSMAWLNPDYAPADPFAATDWLMGRKRGLLAPWAVGTIDQALMAVLRA
KHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWLGTLDVPVVLLSA
TLHHSIANSLVKAYLEGARGRRWNRSEPQPVSEVSYPGWLHVDARIGKVT
RSSDVDPLPIATTPRKPLEVRLVDVPVKEGALNRSTVLAKELTPLVKQGG
CAAIICTTVAEAQGVYDLLSQWFATLAPDLYLLHSRFPNRQRTEITATIV
DLFGKEGAQSGRRPTRGAVLVATQVVEQSLDLDVDLMISDLAPVSLLLQR
AGRCWRHEHLGIINRPQWAKQPELVVLTPEQNRAPWFPRSWTSVYPLALL
QRTYTLLRRRNGAPVQIPEDVQQLVDDVYDDDSLAEDLEADMERMGEELA
QRGLARNAVIPDPDDAEDNLNGLTEFVLATRFGAGSVRVLCYYVDTAGNR
WLDPECTVEFPEQGTGREGRFTMADCRDLVARTIPVRMGPWASQLTEDNH
PPEAWRESFYLRDLVLIPQRVTDEGAVLPTETGGREWLLDPCKGLIF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4qqw Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Resolution2.664 Å
Binding residue
(original residue number in PDB)
K23 D84 K87 H150 D215 W216 S219 E221 T337 M338 S372 R410 K411 R412 T422 D424 Q425 T590 T591 V592 S621 R628 T659 Q660 Q664 R729 S730 S733 R828 G832 S833 R884 F906
Binding residue
(residue number reindexed from 1)
K10 D71 K74 H137 D202 W203 S206 E208 T322 M323 S354 R377 K378 R379 T389 D391 Q392 T557 T558 V559 S585 R592 T623 Q624 Q628 R689 S690 S693 R781 G785 S786 R837 F859
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0051607 defense response to virus
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4qqw, PDBe:4qqw, PDBj:4qqw
PDBsum4qqw
PubMed25132177
UniProtQ47PJ0

[Back to BioLiP]