Structure of PDB 4p6x Chain E Binding Site BS01
Receptor Information
>4p6x Chain E (length=255) Species:
9606
(Homo sapiens) [
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ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVI
AAVKWAKAIPGFRNLHLDDQMTLLQYSWMALMAFALGWRSYRQSSANLLY
FAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKVLLLL
STIPKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL
DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKL
LFHQK
Ligand information
>4p6x Chain F (length=14) Species:
9606
(Homo sapiens) [
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KENALLRYLLDKDD
Receptor-Ligand Complex Structure
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PDB
4p6x
Structures and mechanism for the design of highly potent glucocorticoids.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
V575 K579 R585 L589 M593 E755 N759
Binding residue
(residue number reindexed from 1)
V53 K57 R63 L67 M71 E233 N237
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4p6x
,
PDBe:4p6x
,
PDBj:4p6x
PDBsum
4p6x
PubMed
24763108
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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