Structure of PDB 4ooa Chain E Binding Site BS01

Receptor Information
>4ooa Chain E (length=65) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLINLKIQKENPKVVNEINIEDLSLTKAAYCRCWRSKTFPACDGSCNKHN
ELTGDNVGPLILKKK
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain4ooa Chain E Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ooa A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.
Resolution1.58 Å
Binding residue
(original residue number in PDB)		C99 R100 C101 C110 D111 G112 S113 C114 P127
Binding residue
(residue number reindexed from 1)		C31 R32 C33 C42 D43 G44 S45 C46 P59
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0010506 regulation of autophagy
Cellular Component
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ooa, PDBe:4ooa, PDBj:4ooa
PDBsum4ooa
PubMed24914968
UniProtQ8N5K1|CISD2_HUMAN CDGSH iron-sulfur domain-containing protein 2 (Gene Name=CISD2)

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