Structure of PDB 4mz6 Chain E Binding Site BS01

Receptor Information
>4mz6 Chain E (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4mz6 Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Resolution1.88 Å
Binding residue
(original residue number in PDB)		R315 N319 V321 E354 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		R244 N248 V250 E283 W286 N290 E325 W328
Enzymatic activity
Catalytic site (original residue number in PDB) T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1) T80 A92 N290 R295 Q296
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mz6, PDBe:4mz6, PDBj:4mz6
PDBsum4mz6
PubMed24311590
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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