Structure of PDB 4kzx Chain E Binding Site BS01

Receptor Information
>4kzx Chain E (length=263) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MARGPKKHLKRVAAPKHWMLDKLTSVFAPRPSTGPHKLRECLPLIIFLRN
KLKYALTGDEVKKICMQRFIKIDGKVRADITYPAGFMDVISIDKTGENFR
LIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYP
DPLIKMNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRER
HPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAE
ERDKRLAAKQSSG
Ligand information
>4kzx Chain i (length=1797) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagccuccccg
ccggccggggggguggggcggcggcuuuggugacucuagauaaccucggg
ccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccua
ucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacg
gggaaucaggguucgauuccggagagggagccugagaaacggcuaccaca
uccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagg
uagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauugga
augaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucug
gucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugc
ugcaguuaaaaagcucguaguuggaucuuggagggugcguagcgggccac
cgcccguccccgccuugccuccgaagcguuuacuuugaaaaaauuagagu
guucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauucugug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccg
agcggucggcgucccccaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugc
acgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcagg
cgcggguaacccguugaaccccauucgugauggggaucggggauugcaau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauu
ggaugguuuagugaggcccucggaucggcccgccggggucggcccacggc
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[....................<<.....
<<.<<<.....>>>.>>......>>.........<<<...<<.<......
>.>>...>>>.[[..(((((.....<<<<<<<<<<<<.<...<.<<<...
.......>..>.>.>.....>>>>..............)))))......]
]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<.
...<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<
<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.
<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>
>......}}.......<<<<<<<<<.<<<....>>>.>.>>>>>.>>>..
....<<..<...........>..>>.........<<<<<((......<<<
<.....<<..))>>.......>>>>.>>>>>..)))))).]]].......
.....{{.......{{...[[[.[[.......<<<...<..<........
>..>...>>>......<<.<...>.>>..<<<<<..<.......<<...<
.......>.<<<<.......>>>>...>>......>..>>..>>>.....
..[[....(((((((.....>>>>>>>>>.)))))))...]]....]]..
..<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>...
...>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>.
..]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...
>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>
>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<..
....<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..
<<<<<..<<<.<<<<<<......<<........>>..........<<<<<
......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>
.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<
<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>....>>>.>>>...>.>>>>>>>>.....>>>>>...>>
.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>
>>.>>>....>.........>>>.>>............<<<<<.......
...>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>
>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....
<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<.....>>>>
>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>
...>.>>.........<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kzx The initiation of mammalian protein synthesis and mRNA scanning mechanism.
Resolution7.809 Å
Binding residue
(original residue number in PDB)
M1 A2 R3 K7 H8 K10 V12 M19 D21 K22 L23 S25 V26 F27 P29 T33 G34 K37 L38 T57 G58 M66 R77 K106 R108 R127 V131 G132 K134 G135 A144 T146 R148 G186 A187 H201 A219 R221 I248 R255
Binding residue
(residue number reindexed from 1)
M1 A2 R3 K7 H8 K10 V12 M19 D21 K22 L23 S25 V26 F27 P29 T33 G34 K37 L38 T57 G58 M66 R77 K106 R108 R127 V131 G132 K134 G135 A144 T146 R148 G186 A187 H201 A219 R221 I248 R255
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4kzx, PDBe:4kzx, PDBj:4kzx
PDBsum4kzx
PubMed23873042
UniProtG1TK17|RS4X_RABIT Small ribosomal subunit protein eS4 (Gene Name=RPS4X)

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