Structure of PDB 4k4s Chain E Binding Site BS01

Receptor Information

>4k4s Chain E (length=462) Species: 12081 (Human poliovirus 1 Mahoney) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRL
KTDFEEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQMCLEDA
MYGTDGLEALDLSTSAGYPYVAMGKKKRDILNKQTRDTKEMQKLLDTYGI
NLPLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMRMAFGNLYAAFHK
NPGVITGSAVGCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFEALK
MVLEKIGFGDRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTSIFNSMI
NNLIIRTLLLKTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQSGKDY
GLTMTPADKSATFETVTWENVTFLKRFFRADEKYPFLIHPVMPMKEIHES
IRWTKDPRNTQDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIGRALDLPEY
STLYRRWLDSFG

Ligand information

>4k4s Chain F (length=17) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

uccaggucucucgcgaa

.................

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4k4s Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	N18 P20 K24 E108 T114 S115 K127 Y157 K159 I176 E177 A178 R188 H199 G211 C212 D213 S288 G289 C290 S291 L419
Binding residue (residue number reindexed from 1)	N18 P20 K24 E108 T114 S115 K127 Y157 K159 I176 E177 A178 R188 H199 G211 C212 D213 S288 G289 C290 S291 L419

Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity

	Biological Process
GO:0006351	DNA-templated transcription
GO:0039694	viral RNA genome replication

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Molecular Function

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Biological Process

External links

PDB	RCSB:4k4s, PDBe:4k4s, PDBj:4k4s
PDBsum	4k4s
PubMed	23667424
UniProt	P03300\|POLG_POL1M Genome polyprotein

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