Structure of PDB 4j9d Chain E Binding Site BS01

Receptor Information

>4j9d Chain E (length=59) Species: 9606 (Homo sapiens)

DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWV
PSAYITPVN

Ligand information

>4j9d Chain F (length=10) Species: 9606 (Homo sapiens)

APTYPPPLPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4j9d Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): Y70 S75 D77 W99 W110 P112 Y115
• Binding residue (residue number reindexed from 1): Y9 S14 D16 W38 W49 P51 Y54

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

External links

• PDB: RCSB:4j9d, PDBe:4j9d, PDBj:4j9d
• PDBsum: 4j9d
• UniProt: P00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)