Structure of PDB 4ig9 Chain E Binding Site BS01

Receptor Information
>4ig9 Chain E (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYA
RLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIA
LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCE
AVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKD
EVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGD
CDVIINELCHRLGGEYAKLC
Ligand information
>4ig9 Chain B (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSQYLFLPPNRYIFHGAEVYS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4ig9 Structural and Functional Analysis of Human SIRT1.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		K444 R446 A449 L450 P470 H471 H473
Binding residue
(residue number reindexed from 1)		K213 R215 A218 L219 P239 H240 H242
Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P40 D41 F42 R43 N115 D117 H132
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4ig9, PDBe:4ig9, PDBj:4ig9
PDBsum4ig9
PubMed24120939
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

[Back to BioLiP]