Structure of PDB 4i5b Chain E Binding Site BS01

Receptor Information
>4i5b Chain E (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTRPRFLWQLKFECHFFNGTERVRLLERSIYNQEESVRFDSDVGEYRAVT
ELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVTV
YPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4i5b Disruption of hydrogen bonds between major histocompatibility complex class II and the peptide N-terminus is not sufficient to form a human leukocyte antigen-DM receptive state of major histocompatibility complex class II.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		L11 F13 Y47 D57 Y60 W61 L67 Q70 R71 Y78 H81 N82
Binding residue
(residue number reindexed from 1)		L10 F12 Y46 D56 Y59 W60 L66 Q69 R70 Y77 H80 N81
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4i5b, PDBe:4i5b, PDBj:4i5b
PDBsum4i5b
PubMed23976922
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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