Structure of PDB 4cs8 Chain E Binding Site BS01

Receptor Information

>4cs8 Chain E (length=161) Species: 162145 (human metapneumovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KAPCKYEVRGKCNRGSECKFNHNYWSWPDRYLLIRSNYLLNQLLRNTDRE
DRTQDFVLGSTNVVQGYIDDNQSITKAAACYSLHNIIKQLQEVEVRQARD
NKLSDSKHVALHNLVLSYMEMSKTPASLINNLKRLPREKLKKLAKLIIDL
SAGAENDSSYA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4cs8 Chain E Residue 1177 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4cs8 Drastic Changes in Conformational Dynamics of the Antiterminator M2-1 Regulate Transcription Efficiency in Pneumovirinae.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	C7 C15 C21 H25
Binding residue (residue number reindexed from 1)	C4 C12 C18 H22
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003746	translation elongation factor activity
GO:0005198	structural molecule activity
GO:0046872	metal ion binding

	Biological Process
GO:0006414	translational elongation
GO:0046782	regulation of viral transcription

	Cellular Component
GO:0005737	cytoplasm
GO:0030430	host cell cytoplasm
GO:0042025	host cell nucleus
GO:0044423	virion component

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4cs8, PDBe:4cs8, PDBj:4cs8
PDBsum	4cs8
PubMed	24842877
UniProt	Q8QN58

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