Structure of PDB 3vc1 Chain E Binding Site BS01
Receptor Information
>3vc1 Chain E (length=278) Species:
100226
(Streptomyces coelicolor A3(2)) [
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PAPATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGPVDRAALGDP
EHSEYEKKVIAELHRLESAQAEFLMDHLGQAGPDDTLVDAGCGRGGSMVM
AHRRFGSRVEGVTLSAAQADFGNRRARELRIDDHVRSRVCNMLDTPFDKG
AVTASWNNESTMYVDLHDLFSEHSRFLKVGGRYVTITGCWNPRYGQPSKW
VSQINAHFECNIHSRREYLRAMADNRLVPHTIVDLTPDTLPYWELRATSS
LVTGIEKAFIESYRDGSFQYVLIAADRV
Ligand information
Ligand ID
SAH
InChI
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKey
ZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
Software
SMILES
CACTVS 3.341
N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04
O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
Formula
C14 H20 N6 O5 S
Name
S-ADENOSYL-L-HOMOCYSTEINE
ChEMBL
CHEMBL418052
DrugBank
DB01752
ZINC
ZINC000004228232
PDB chain
3vc1 Chain E Residue 302 [
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Receptor-Ligand Complex Structure
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PDB
3vc1
Structure of Geranyl Diphosphate C-Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification.
Resolution
1.82 Å
Binding residue
(original residue number in PDB)
Q22 W29 H49 H50 G105 G107 T127 L128 Q132 C154 N155 M156 N172 Y177
Binding residue
(residue number reindexed from 1)
Q8 W15 H35 H36 G91 G93 T113 L114 Q118 C140 N141 M142 N158 Y163
Annotation score
5
Enzymatic activity
Enzyme Commision number
2.1.1.255
: geranyl diphosphate 2-C-methyltransferase.
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0008168
methyltransferase activity
GO:0008169
C-methyltransferase activity
GO:0008757
S-adenosylmethionine-dependent methyltransferase activity
GO:1904047
S-adenosyl-L-methionine binding
Biological Process
GO:0032259
methylation
GO:0042214
terpene metabolic process
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:3vc1
,
PDBe:3vc1
,
PDBj:3vc1
PDBsum
3vc1
PubMed
22455498
UniProt
Q9F1Y5
|GPPMT_STRCO Geranyl diphosphate 2-C-methyltransferase (Gene Name=SCO7701)
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