Structure of PDB 3tpx Chain E Binding Site BS01

Receptor Information
>3tpx Chain E (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
Ligand information
Receptor-Ligand Complex Structure
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PDB3tpx An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		L54 F55 G58 I61 Y67 Q72 H73 V93 K94 I99 Y100
Binding residue
(residue number reindexed from 1)		L30 F31 G34 I37 Y43 Q48 H49 V69 K70 I75 Y76
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3tpx, PDBe:3tpx, PDBj:3tpx
PDBsum3tpx
PubMed22694121
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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