Structure of PDB 3siv Chain E Binding Site BS01

Receptor Information
>3siv Chain E (length=236) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDY
IRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELE
RLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVA
GGLTNLSKMPACNIMLLGAQVLPHTGYIYHSDIVQSLPPDLRRKAARLVA
AKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQ
Ligand information
>3siv Chain C (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uacuguccaaugagcgcauagugagggcagua
................................
Receptor-Ligand Complex Structure
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PDB3siv Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
Resolution3.304 Å
Binding residue
(original residue number in PDB)		M250 P269 H270 R289 R293 K298 K327 K330
Binding residue
(residue number reindexed from 1)		M165 P173 H174 R193 R197 K202 K231 K234
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0046540 U4/U6 x U5 tri-snRNP complex

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3siv, PDBe:3siv, PDBj:3siv
PDBsum3siv
PubMed21784869
UniProtQ8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Gene Name=PRPF31)

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