Structure of PDB 3s5l Chain E Binding Site BS01

Receptor Information
>3s5l Chain E (length=191) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRA
VTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKV
TVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQ
NGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3s5l Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		F13 Y47 P56 D57 Y60 W61 L67 Q70 R71 Y78 H81 N82 V85
Binding residue
(residue number reindexed from 1)		F14 Y48 P57 D58 Y61 W62 L68 Q71 R72 Y79 H82 N83 V86
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:3s5l, PDBe:3s5l, PDBj:3s5l
PDBsum3s5l
PubMed21900604
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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