Structure of PDB 3pla Chain E Binding Site BS01

Receptor Information

>3pla Chain E (length=227) Species: 2287 (Saccharolobus solfataricus)

ITVKQTNMENIYECEFNDGSFRLCTRNLVPNFNVYGERLIKYEGVEYREW
NAFRSKLAGAILKGLKTNPIRKGTKVLYLGAASGTTISHVSDIIELNGKA
YGVEFSPRVVRELLLVAQRRPNIFPLLADARFPQSYKSVVENVDVLYVDI
AQPDQTDIAIYNAKFFLKVNGDMLLVIKARSIDVTKDPKEIYKTEVEKLE
NSNFETIQIINLDPYDKDHAIVLSKYK

Ligand information

>3pla Chain G (length=35)

gggagucuugugaugaaacacucauggucugaaga

...................................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3pla Structural basis for site-specific ribose methylation by box C/D RNA protein complexes.
• Resolution: 3.15 Å
• Binding residue (original residue number in PDB): S110 R112 A155 P157 R184 S185 D187 V188
• Binding residue (residue number reindexed from 1): S106 R108 A151 P153 R180 S181 D183 V184

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0008168 methyltransferase activity
• GO:0008649 rRNA methyltransferase activity
• GO:0016740 transferase activity
• GO:1990259 histone H2AQ104 methyltransferase activity

Biological Process

• GO:0000494 box C/D sno(s)RNA 3'-end processing
• GO:0006338 chromatin remodeling
• GO:0006364 rRNA processing
• GO:0008033 tRNA processing
• GO:0031167 rRNA methylation
• GO:0032259 methylation

Cellular Component

• GO:0031428 box C/D methylation guide snoRNP complex

External links

• PDB: RCSB:3pla, PDBe:3pla, PDBj:3pla
• PDBsum: 3pla
• PubMed: 21270896
• UniProt: P58032|FLPA_SACS2 Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase (Gene Name=flpA)