Structure of PDB 3pio Chain E Binding Site BS01

Receptor Information
>3pio Chain E (length=171) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKQPIAVPSGVTVNAQDGVFKVKGPKGELTVPYNTELTVRQDGDQLLVER
PSDAQKHRALHGLTRTLVANAVKGVSDGYTINLELRGVGFRAKLTGKALE
MNIGYSHPVIIEPPAGVTFAVPEPTRIDVSGIDKQLVGQVAANVRKVRKP
DAYHGKGVRFVGEQIALKAGK
Ligand information
>3pio Chain X (length=2657) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaauc
aagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguagg
cgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggacca
ccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugag
ggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccg
uggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauu
gaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaa
cggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucggg
cuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggg
gggcggaggaccgaaccggugccugcugaaacagucucggaugaguugug
uuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaa
auguauugagguacagccucggauguugaccauguccuguagagcacuca
caaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggag
ugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagacc
aucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucg
cauagacagccaggagguuggcuuagaagcagccacccuucaaagagugc
guaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcuca
agugaucuaccgaagcuauggauucaacucggaguugucugguaggggag
cguucaguccgcggagaagccauaccggaaggagugguggagccgacuga
agugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucg
ccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucg
ggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagau
uccugcaccgaucauguggagugauggagggacgcauuacgcuauccaau
gccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucaga
aaaucuaccggucugccucagacguaucgggagcuuccucggaagcgaag
uuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauu
gcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcg
cgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucg
gaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggc
gacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguau
agggugugacgccugcccggugccggaaggucaaguggagcggugcaagc
ugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucgg
guaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaac
gagggacucggugaaauugaauuggcuguaaagaugcggccuacccguag
caggacgaaaagaccccguggagcuuuacuauagucuggcauugggauuc
ggguuacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuug
gcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcc
caaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguag
aagguggcuugacugcgagacugacacgucgagcagggaggaaacucggg
cuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaa
aguuaccccggggauaacaggcugaucucccccgagaguccauaucggcg
gggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaa
ggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcugggu
ucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggaga
auugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcu
ggucucccugcugucguaccaacggcacaugcaggguagcuauguccgga
acggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugagu
ucucccacugagguaagacucccggaagaccaccggguuaagaggccagg
cgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggu
cuugacc
.<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<
..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>
>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..(((
(>>>>>..>>>......>>.>>>>>>.>>..............<<....>
>....>>.........<<<<....>>>>..................>>>>
>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.....
.......>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>
>...>>>...<<....>>...<........>.........>>>>>>>>>>
>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>
>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>
>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<...
.<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<
.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>
>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<
<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<
........<<<<<.<<...<<<<.......>>>>...>>.........<<
......>>...>>>>>....>>>>>>>>>.>>..........))).....
.>>>>>>.>>>...>>>>>>><..<<<<.....>>>>..>....>>>>>>
<.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>
>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<
<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<
<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<.......
.>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.
<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<.<<<<<<...<<.
....>>.>>>>>>..>>>..>>>>>>>>>...<<<<<....>>>>>....
>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>
..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>
>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<
<..<<...........>>..<<<<<<<.....<<<.....>>>.......
>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>
>>>...>>...>>>>>>>>..>>>>........<...........<<<<<
.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<
<<<<.>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>
>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<
<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>..
..>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>
))).......<<<<<<<.<<..))))..>>>>>>>>>.............
>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>
>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......
>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>.
...<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<
<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....
<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>..
..<<....<<<<<...........>>>>>....>>..>>>>.......>>
>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.
<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>
>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pio Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
Resolution3.2473 Å
Binding residue
(original residue number in PDB)		K6 A63 L67 T70 Y109 S110 H111 Q139 G142 Q143 A146 K150 K153 Y157 H158 K160
Binding residue
(residue number reindexed from 1)		K2 A59 L63 T66 Y105 S106 H107 Q135 G138 Q139 A142 K146 K149 Y153 H154 K156
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3pio, PDBe:3pio, PDBj:3pio
PDBsum3pio
PubMed21282615
UniProtQ9RSL3|RL6_DEIRA Large ribosomal subunit protein uL6 (Gene Name=rplF)

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