Structure of PDB 3kds Chain E Binding Site BS01

Receptor Information
>3kds Chain E (length=427) Species: 2336 (Thermotoga maritima) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRVTFKDVGGAEEAIEELKEVVEFLKDPSKFNRIGARMPKGILLVGPPGT
GATLLARAVAGEANVPFFHISGSDFVELFVGVGAARVRDLFAQAKAHAPC
IVFIDEIDAVGRHDEREQTLNQLLVEMDGFDSKEGIIVMAATNRPDILDP
ALLRPGRFDKKIVVDPPDMLGRKKILEIHTRNKPLAEDVNLEIIAKRTPG
FVGADLENLVNEAALLAAREGRDKITMKDFEEAIDRVIAGPARKSLLISP
AEKRIIAYHEAGHAVVSTVVPNGEPVHRISIIPRGYKALGYTLHLPEEDK
YLVSRNELLDKLTALLGGRAAEEVVFGDVTSGAANDIERATEIARNMVCQ
LGMSEELGPLAWGKRLRNYSEEVASKIDEEVKKIVTNCYERAKEIIRKYR
KQLDNIVEILLEKETIEGDELRRILSE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3kds Chain E Residue 996 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3kds The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation
Resolution2.601 Å
Binding residue
(original residue number in PDB)		H423 H427 D500
Binding residue
(residue number reindexed from 1)		H259 H263 D336
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kds, PDBe:3kds, PDBj:3kds
PDBsum3kds
PubMed19955424
UniProtQ9WZ49|FTSH_THEMA ATP-dependent zinc metalloprotease FtsH (Gene Name=ftsH)

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