Structure of PDB 3k7r Chain E Binding Site BS01

Receptor Information
>3k7r Chain E (length=72) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQLVDVYTTL
PYDFILEKIKKTGKEVRSGKQL
Ligand information
Ligand ID4SM
InChIInChI=1S/Mo.4S/q;;;2*-1
InChIKeyCXVCSRUYMINUSF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0[S-][Mo](=S)(=S)[S-]
ACDLabs 11.02
CACTVS 3.352		[S-][Mo]([S-])(=S)=S
FormulaMo S4
NameTETRATHIOMOLYBDATE
ChEMBL
DrugBankDB05088
ZINC
PDB chain3k7r Chain D Residue 76 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3k7r Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		T14 C15 C18
Binding residue
(residue number reindexed from 1)		T13 C14 C17
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016531 copper chaperone activity
GO:0046872 metal ion binding
Biological Process
GO:0006825 copper ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0034599 cellular response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3k7r, PDBe:3k7r, PDBj:3k7r
PDBsum3k7r
PubMed19965379
UniProtP38636|ATX1_YEAST Copper chaperone ATX1 (Gene Name=ATX1)

[Back to BioLiP]