Structure of PDB 3izo Chain E Binding Site BS01

Receptor Information

>3izo Chain E (length=455) Species: 28285 (Human adenovirus 5)

DPPFVPPRYLRPTGGRNSIRYSELAPLFDTTRVYLVDNKSTDVASLNYQN
DHSNFLTTVIQNNDYSPGEASTQTINLDDRSHWGGDLKTILHTNMPNVNE
FMFTNKFKARVMVSRLPTKDNQVELKYEWVEFTLPEGNYSETMTIDLMNN
AIVEHYLKVGRQNGVLESDIGVKFDTRNFRLGFDPVTGLVMPGVYTNEAF
HPDIILLPGCGVDFTHSRLSNLLGIRKRQPFQEGFRITYDDLEGGNIPAL
LDVDAYQASLKKPVIKPLTEDSKKRSYNLISNDSTFTQYRSWYLAYNYGD
PQTGIRSWTLLCTPDVTCGSEQVYWSLPDMMQDPVTFRSTRQISNFPVVG
AELLPVHSKSFYNDQAVYSQLIRQFTSLTHVFNRFPENQILARPPAPTIT
TVSENVPALTDHGTLPLRNSIGGVQRVTITDARRRTCPYVYKALGIVSPR
VLSSR

Ligand information

>3izo Chain H (length=13) Species: 28285 (Human adenovirus 5)

SEDTFNPVYPYDT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3izo Model of the Trimeric Fiber and Its Interactions with the Pentameric Penton Base of Human Adenovirus by Cryo-electron Microscopy.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): L193 R197 E203 T493 H494 R498 F499
• Binding residue (residue number reindexed from 1): L157 R161 E167 T379 H380 R384 F385

Gene Ontology

Molecular Function

• GO:0005198 structural molecule activity

Biological Process

• GO:0019062 virion attachment to host cell
• GO:0046718 symbiont entry into host cell
• GO:0075509 endocytosis involved in viral entry into host cell
• GO:0075512 clathrin-dependent endocytosis of virus by host cell

Cellular Component

• GO:0019028 viral capsid
• GO:0039623 T=25 icosahedral viral capsid
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:3izo, PDBe:3izo, PDBj:3izo
• PDBsum: 3izo
• PubMed: 21146538
• UniProt: P12538|CAPSP_ADE05 Penton protein (Gene Name=L2)