Structure of PDB 3hus Chain E Binding Site BS01

Receptor Information

>3hus Chain E (length=303) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPV
VSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNR
QDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRM
GPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMD
GASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYN
RCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIR
PFF

Ligand information

>3hus Chain J (length=4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GPRP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3hus Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and "A:a" interactions.
Resolution	3.04 Å
Binding residue (original residue number in PDB)	L360 W385 E397 D398 R406 C407 H408 T431 D432
Binding residue (residue number reindexed from 1)	L205 W230 E242 D243 R251 C252 H253 T276 D277

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005102	signaling receptor binding

	Biological Process
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0051258	protein polymerization

	Cellular Component
GO:0005577	fibrinogen complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3hus, PDBe:3hus, PDBj:3hus
PDBsum	3hus
PubMed	19650644
UniProt	P02675\|FIBB_HUMAN Fibrinogen beta chain (Gene Name=FGB)

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