Structure of PDB 3h8g Chain E Binding Site BS01

Receptor Information
>3h8g Chain E (length=497) Species: 303 (Pseudomonas putida) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MELVVKSVAAASVKTATLVIPVGENRKLGAVAKAVDLASEGAISAVLKRG
DLAGKPGQTLLLQNLQGLKAERVLLVGSGKDEALGDRTWRKLVASVAGVL
KGLNGADAVLALDDVAVNNRDAHYGKYRLLAETLLDGEYVFDRFKSQKVE
PRALKKVTLLADKAGQAEVERAVKHASAIATGMAFTRDLGNLPPNLCHPS
FLAEQAKELGKAHKALKVEVLDEKKIKDLGMGAFYAVGQGSDQPPRLIVL
NYQGGKKADKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGT
LRAVLELQLPVNLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDA
EGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTTGLMGNNDDLV
GQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADMGNIGGPKAGTITAGCF
LSRFAKAYNWAHMDIAGTAWISGGKDKGATGRPVPLLTQYLLDRAGA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3h8g Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3h8g Crystal structure of the leucine aminopeptidase from Pseudomonas putida reveals the molecular basis for its enantioselectivity and broad substrate specificity.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		K267 D272 D290 E351
Binding residue
(residue number reindexed from 1)		K267 D272 D290 E351
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) K279 R353
Catalytic site (residue number reindexed from 1) K279 R353
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.10: bacterial leucyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3h8g, PDBe:3h8g, PDBj:3h8g
PDBsum3h8g
PubMed20359484
UniProtO86436|AMPA_PSEPU Cytosol aminopeptidase (Gene Name=pepA)

[Back to BioLiP]