Structure of PDB 3h1l Chain E Binding Site BS01

Receptor Information

>3h1l Chain E (length=196) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VHNDVTVPDFSAYRREDVMDATTSSQTSSEDRKGFSYLVTATACVATAYA
AKNVVTQFISSLSASADVLALSKIEIKLSDIPEGKNVAFKWRGKPLFVRH
RTQAEINQEAEVDVSKLRDPQHDLDRVKKPEWVILVGVCTHLGCVPIANS
GDFGGYYCPCHGSHYDASGRIRKGPAPYNLEVPTYQFVGDDLVVVG

Ligand information

InChI=1S/2Fe.2S

NIXDOXVAJZFRNF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04	[Fe]1S[Fe]S1
CACTVS 3.341 OpenEye OEToolkits 1.5.0	S1[Fe]S[Fe]1

Formula

Fe2 S2

Name

FE2/S2 (INORGANIC) CLUSTER

ChEMBL

DrugBank

ZINC

PDB chain

3h1l Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3h1l Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc(1) complex.
Resolution	3.21 Å
Binding residue (original residue number in PDB)	C139 H141 L142 C144 C158 H161 S163
Binding residue (residue number reindexed from 1)	C139 H141 L142 C144 C158 H161 S163
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H161
Catalytic site (residue number reindexed from 1)	H161
Enzyme Commision number	7.1.1.8: quinol--cytochrome-c reductase.

Gene Ontology

	Molecular Function
GO:0008121	ubiquinol-cytochrome-c reductase activity
GO:0051537	2 iron, 2 sulfur cluster binding

	Cellular Component
GO:0016020	membrane

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:3h1l, PDBe:3h1l, PDBj:3h1l
PDBsum	3h1l
PubMed	20025846
UniProt	Q5ZLR5\|UCRI_CHICK Cytochrome b-c1 complex subunit Rieske, mitochondrial (Gene Name=UQCRFS1)

[Back to BioLiP]