Structure of PDB 3enz Chain E Binding Site BS01
Receptor Information
>3enz Chain E (length=243) Species:
36329
(Plasmodium falciparum 3D7) [
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NLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVEC
HYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKR
GDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNG
ISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGI
LIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
Ligand information
Ligand ID
HPA
InChI
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChIKey
FDGQSTZJBFJUBT-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
O=C1c2c(N=CN1)ncn2
OpenEye OEToolkits 1.5.0
c1[nH]c2c(n1)N=CNC2=O
CACTVS 3.341
O=C1NC=Nc2nc[nH]c12
Formula
C5 H4 N4 O
Name
HYPOXANTHINE
ChEMBL
CHEMBL1427
DrugBank
DB04076
ZINC
ZINC000018153302
PDB chain
3enz Chain E Residue 301 [
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Receptor-Ligand Complex Structure
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PDB
3enz
Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases.
Resolution
2.03 Å
Binding residue
(original residue number in PDB)
S91 C92 G93 Y160 D206
Binding residue
(residue number reindexed from 1)
S89 C90 G91 Y158 D204
Annotation score
5
Enzymatic activity
Catalytic site (original residue number in PDB)
H7 G23 R27 R45 E77 R88 S91 D206 G207 P209 V222
Catalytic site (residue number reindexed from 1)
H5 G21 R25 R43 E75 R86 S89 D204 G205 P207 V220
Enzyme Commision number
2.4.2.1
: purine-nucleoside phosphorylase.
2.4.2.44
: S-methyl-5'-thioinosine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0004731
purine-nucleoside phosphorylase activity
GO:0004850
uridine phosphorylase activity
GO:0016757
glycosyltransferase activity
GO:0017061
S-methyl-5-thioadenosine phosphorylase activity
GO:0047975
guanosine phosphorylase activity
Biological Process
GO:0006148
inosine catabolic process
GO:0006166
purine ribonucleoside salvage
GO:0006195
purine nucleotide catabolic process
GO:0006218
uridine catabolic process
GO:0009116
nucleoside metabolic process
Cellular Component
GO:0005829
cytosol
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Molecular Function
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Cellular Component
External links
PDB
RCSB:3enz
,
PDBe:3enz
,
PDBj:3enz
PDBsum
3enz
PubMed
19575810
UniProt
Q8I3X4
|PNPH_PLAF7 Purine nucleoside phosphorylase (Gene Name=PNP)
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