Structure of PDB 3bef Chain E Binding Site BS01

Receptor Information
>3bef Chain E (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRNI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
Receptor-Ligand Complex Structure
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PDB3bef Structural identification of the pathway of long-range communication in an allosteric enzyme.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E127 G133 Y134 F204A
Binding residue
(residue number reindexed from 1)		E124 G133 Y134 F209
Enzymatic activity
Catalytic site (original residue number in PDB) H57 N102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 N99 E196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3bef, PDBe:3bef, PDBj:3bef
PDBsum3bef
PubMed18250335
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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