Structure of PDB 2qts Chain E Binding Site BS01

Receptor Information

>2qts Chain E (length=421) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SLKRVVWALCFMGSLALLALVCTNRIQYYFLYPHVTKLDEVAATRLTFPA
VTFCNLNEFRFSRVTKNDLYHAGELLALLNNRYEIPDTQTADEKQLEILQ
DKANFRNFKPKPFNMLEFYDRAGHDIREMLLSCFFRGEQCSPEDFKVVFT
RYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDET
SFEAGIKVQIHSQDEPPLIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWGD
CKATTGDSEFYDTYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQ
YKECADPALDFLVEKDNEYCVCEMPCNVTRYGKELSMVKIPSKASAKYLA
KKYNKSEQYIGENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGL
FIGASILTVLELFDYAYEVIK

Ligand information

Ligand ID

InChI

InChI=1S/ClH/h1H/p-1

InChIKey

VEXZGXHMUGYJMC-UHFFFAOYSA-M

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Cl-]

Formula

Name

CHLORIDE ION

PDB chain

2qts Chain E Residue 5 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2qts Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Resolution	1.9 Å
Binding residue (original residue number in PDB)	R310 E314
Binding residue (residue number reindexed from 1)	R270 E274
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005272	sodium channel activity
GO:0015280	ligand-gated sodium channel activity

	Biological Process
GO:0006814	sodium ion transport

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:2qts, PDBe:2qts, PDBj:2qts
PDBsum	2qts
PubMed	17882215
UniProt	Q1XA76\|ASIC1_CHICK Acid-sensing ion channel 1 (Gene Name=ASIC1)

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