Structure of PDB 2j3u Chain E Binding Site BS01

Receptor Information

>2j3u Chain E (length=218) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPCLTGPRTCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVF
QRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNIHALTAQGTSELRTDL
VDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNNQSFST
KDQDNDLNTGNCAVMFQGAWWYKNCHTSNLNGRYLRGTHGSFANGINWKS
GKGYNYSYKVSEMKVRPA

Ligand information

Ligand ID

GLA

InChI

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1

InChIKey

WQZGKKKJIJFFOK-PHYPRBDBSA-N

SMILES

Software	SMILES
CACTVS 3.341	OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.5.0	C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0	C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341	OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 10.04	OC1C(O)C(OC(O)C1O)CO

Formula

C6 H12 O6

Name

alpha-D-galactopyranose;
alpha-D-galactose;
D-galactose;
galactose;
ALPHA D-GALACTOSE

PDB chain

2j3u Chain E Residue 1289 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2j3u Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins.
Resolution	2.15 Å
Binding residue (original residue number in PDB)	R132 D133 T136 K221
Binding residue (residue number reindexed from 1)	R62 D63 T66 K151
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:2j3u, PDBe:2j3u, PDBj:2j3u
PDBsum	2j3u
PubMed	17215869
UniProt	Q15485\|FCN2_HUMAN Ficolin-2 (Gene Name=FCN2)

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