Structure of PDB 2fyu Chain E Binding Site BS01

Receptor Information

>2fyu Chain E (length=196) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYA
AKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRH
RTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCTHLGCVPIANA
GDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPSYEFTSDDMVIVG

Ligand information

InChI=1S/2Fe.2S

NIXDOXVAJZFRNF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04	[Fe]1S[Fe]S1
CACTVS 3.341 OpenEye OEToolkits 1.5.0	S1[Fe]S[Fe]1

Formula

Fe2 S2

Name

FE2/S2 (INORGANIC) CLUSTER

ChEMBL

DrugBank

ZINC

PDB chain

2fyu Chain E Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2fyu Surface-modulated motion switch: Capture and release of iron-sulfur protein in the cytochrome bc1 complex.
Resolution	2.26 Å
Binding residue (original residue number in PDB)	C139 H141 L142 C144 C158 C160 H161 S163
Binding residue (residue number reindexed from 1)	C139 H141 L142 C144 C158 C160 H161 S163
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H161
Catalytic site (residue number reindexed from 1)	H161
Enzyme Commision number	7.1.1.8: quinol--cytochrome-c reductase.

Gene Ontology

	Molecular Function
GO:0008121	ubiquinol-cytochrome-c reductase activity
GO:0051537	2 iron, 2 sulfur cluster binding

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:2fyu, PDBe:2fyu, PDBj:2fyu
PDBsum	2fyu
PubMed	16924113
UniProt	P13272\|UCRI_BOVIN Cytochrome b-c1 complex subunit Rieske, mitochondrial (Gene Name=UQCRFS1)

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