Structure of PDB 2ejw Chain E Binding Site BS01

Receptor Information

>2ejw Chain E (length=331) Species: 300852 (Thermus thermophilus HB8)

MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPR
AIPQELLRAEPFDLLEADLVVEAMGGVEAPLRLVLPALEAGIPLITANKA
LLAEAWESLRPFAEEGLIYHEASVMAGTPALSFLETLRGSELLELHGILN
GTTLYILQEMEKGRTYAEALLEAQRLGYAEADPTLDVEGIDAAHKLTLLA
RLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVASLFGEGGRWR
AAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFA
DLLRFLSGAPGHLPAPRARPPLEEGSPWPGV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2ejw Chain E Residue 2006

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ejw Crystal Structure of Homoserine Dehydrogenase from Thermus thermophilus HB8
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): E121 V124 M125 A126 T128
• Binding residue (residue number reindexed from 1): E121 V124 M125 A126 T128
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D191 K195
• Catalytic site (residue number reindexed from 1): D191 K195
• Enzyme Commision number: 1.1.1.3: homoserine dehydrogenase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004412 homoserine dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050661 NADP binding

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0009086 methionine biosynthetic process
• GO:0009088 threonine biosynthetic process

External links

• PDB: RCSB:2ejw, PDBe:2ejw, PDBj:2ejw
• PDBsum: 2ejw
• UniProt: Q5SL04