Structure of PDB 2bqz Chain E Binding Site BS01

Receptor Information
>2bqz Chain E (length=161) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDF
VVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETN
RLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSK
ASIEAHPWLKH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2bqz Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Resolution1.5 Å
Binding residue
(original residue number in PDB)		Y245 E259 Y262 A263 D265 T268 G269 C270 M272 Y273 Y274 Q276 T307 L309 Y334 Y336 G337 D338 R339 S343 H347 W349
Binding residue
(residue number reindexed from 1)		Y54 E68 Y71 A72 D74 T77 G78 C79 M81 Y82 Y83 Q85 T116 L118 Y143 Y145 G146 D147 R148 S152 H156 W158
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2bqz, PDBe:2bqz, PDBj:2bqz
PDBsum2bqz
PubMed15933069
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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