Structure of PDB 1x27 Chain E Binding Site BS01
Receptor Information
>1x27 Chain E (length=163) Species:
9606
(Homo sapiens) [
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NLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPF
NFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSF
SLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNAS
DGLCTRLSRPCQT
Ligand information
>1x27 Chain M (length=5) Species:
10116
(Rattus norvegicus) [
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YDYVH
Receptor-Ligand Complex Structure
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PDB
1x27
Molecular basis for regulation of Src by the docking protein p130Cas
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
R134 R154 S156 E157 S158 S164 K179 H180 Y181 K182 S194 G215 C217
Binding residue
(residue number reindexed from 1)
R71 R91 S93 E94 S95 S101 K116 H117 Y118 K119 S131 G152 C154
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:1x27
,
PDBe:1x27
,
PDBj:1x27
PDBsum
1x27
PubMed
16245368
UniProt
P06239
|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)
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