Structure of PDB 1v3q Chain E Binding Site BS01

Receptor Information
>1v3q Chain E (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYS
EIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVR
VFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPN
DERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFE
TVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYES
LEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
Ligand information
Ligand ID2DI
InChIInChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChIKeyBXZVVICBKDXVGW-NKWVEPMBSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C1c2ncn(c2N=CN1)C3OC(CC3)CO
OpenEye OEToolkits 1.7.6c1nc2c(n1C3CCC(O3)CO)N=CNC2=O
CACTVS 3.370OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC=Nc23
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3CC[C@H](O3)CO)N=CNC2=O
CACTVS 3.370OC[CH]1CC[CH](O1)n2cnc3C(=O)NC=Nc23
FormulaC10 H12 N4 O3
Name9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE;
2',3'-DIDEOXYINOSINE;
Didanosine
ChEMBLCHEMBL1460
DrugBankDB00900
ZINCZINC000013597823
PDB chain1v3q Chain E Residue 290 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1v3q Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
Resolution2.8 Å
Binding residue
(original residue number in PDB)		G118 F200 E201 V217 M219 N243 H257
Binding residue
(residue number reindexed from 1)		G117 F199 E200 V216 M218 N242 H256
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) S33 H64 Y88 A116 M219 S220 H257
Catalytic site (residue number reindexed from 1) S32 H63 Y87 A115 M218 S219 H256
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0002060 purine nucleobase binding
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042301 phosphate ion binding
GO:0042802 identical protein binding
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0000255 allantoin metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006148 inosine catabolic process
GO:0006149 deoxyinosine catabolic process
GO:0006157 deoxyadenosine catabolic process
GO:0006166 purine ribonucleoside salvage
GO:0006204 IMP catabolic process
GO:0006738 nicotinamide riboside catabolic process
GO:0006955 immune response
GO:0009116 nucleoside metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0009410 response to xenobiotic stimulus
GO:0032743 positive regulation of interleukin-2 production
GO:0034418 urate biosynthetic process
GO:0042102 positive regulation of T cell proliferation
GO:0043101 purine-containing compound salvage
GO:0046059 dAMP catabolic process
GO:0046638 positive regulation of alpha-beta T cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1v3q, PDBe:1v3q, PDBj:1v3q
PDBsum1v3q
PubMed14706628
UniProtP00491|PNPH_HUMAN Purine nucleoside phosphorylase (Gene Name=PNP)

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