Structure of PDB 1uvl Chain E Binding Site BS01

Receptor Information
>1uvl Chain E (length=664) Species: 10879 (Cystovirus phi6) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRRAPAFPLSDIKAQMLFANNIKAQQASKRSFKEGAIETYEGLLSVDPRF
LSFKNELSRYLTDHFPANVDEYGRVYGNGVRTNFFGMRHMNGFPMIPATW
PLASNLKKRADADLADGPVSERDNLLFRAAVRLMFSDLEPVPLKIRKGSS
TCIPYFSNDMGTKIEIAERALEKAEEAGNLMLQGKFDDAYQLHQMGGAYY
VVYRAQSTDAITLDPKTGKFVSKDRMVADFEYAVTGGEQGSLFAASKDAS
RLKEQYGIDVPDGFFCERRRTAMGGPFALNAPIMAVAQPVRNKIYSKYAY
TFHHTTRLNKEEKVKEWSLCVATDVSDHDTFWPGWLRDLICDELLNMGYA
PWWVKLFETSLKLPVYVGAPAPEQGHTLLGDPSNPDLEVGLSSGQGATDL
MGTLLMSITYLVMQLDHTAPHLNSRIKDMPSACRFLDSYWQGHEEIRQIS
KSDDAMLGWTKGRALVGGHRLFEMLKEGKVNPSPYMKISYEHGGAFLGDI
LLYDSRREPGSAIFVGNINSMLNNQFSPEYGVQSGVRDRSKRKRPFPGLA
WASMKDTYGACPIYSDVLEAIERCWWNAFGESYRAYREDMLKRDTLELSR
YVASMARQAGLAELTPIDLEVLADPNKLQYKWTEADVSANIHEVLMHGVS
VEKTERFLRSVMPR
Ligand information
Receptor-Ligand Complex Structure
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PDB1uvl The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		K23 A27 R30 S149 F156 N158 R204 M273 G274 R291 Y295 S393 D399 K451 K543 L628 Q629 T633 E634
Binding residue
(residue number reindexed from 1)		K23 A27 R30 S149 F156 N158 R204 M273 G274 R291 Y295 S393 D399 K451 K543 L628 Q629 T633 E634
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1uvl, PDBe:1uvl, PDBj:1uvl
PDBsum1uvl
PubMed14962391
UniProtP11124|RDRP_BPPH6 RNA-directed RNA polymerase (Gene Name=P2)

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