Structure of PDB 1t5w Chain E Binding Site BS01

Receptor Information
>1t5w Chain E (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSDVGEYRAV
TELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRRVEPKVT
VYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQN
GDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA
Ligand information
>1t5w Chain F (length=13) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAYSDQATPLLLS
Receptor-Ligand Complex Structure
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PDB1t5w A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Resolution2.4 Å
Binding residue
(original residue number in PDB)		L11 F13 P56 D57 Y60 W61 Q70 R71 Y78 H81 N82 V85
Binding residue
(residue number reindexed from 1)		L11 F13 P56 D57 Y60 W61 Q70 R71 Y78 H81 N82 V85
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1t5w, PDBe:1t5w, PDBj:1t5w
PDBsum1t5w
PubMed15489166
UniProtP01911|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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