Structure of PDB 1sgi Chain E Binding Site BS01

Receptor Information
>1sgi Chain E (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>1sgi Chain D (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYID
Receptor-Ligand Complex Structure
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PDB1sgi Molecular dissection of na+ binding to thrombin.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E23 M26 P28 W29 D116 H119 P120 V121 C122 Y134 K135 G136 R137 N159 K186D M201 K202 R206 W207
Binding residue
(residue number reindexed from 1)		E8 M11 P13 W14 D113 H116 P117 V118 C119 Y134 K135 G136 R137 N157 K189 M204 K205 R211 W212
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1sgi, PDBe:1sgi, PDBj:1sgi
PDBsum1sgi
PubMed15152000
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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