Structure of PDB 1sg8 Chain E Binding Site BS01
Receptor Information
>1sg8 Chain E (length=251) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
>1sg8 Chain D (length=27) Species:
9606
(Homo sapiens) [
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ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB
1sg8
Molecular dissection of na+ binding to thrombin.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 G136 R137 N159 M201 K202 N205 R206 W207
Binding residue
(residue number reindexed from 1)
E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N158 M205 K206 N211 R212 W213
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:1sg8
,
PDBe:1sg8
,
PDBj:1sg8
PDBsum
1sg8
PubMed
15152000
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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