Structure of PDB 1r8s Chain E Binding Site BS01

Receptor Information
>1r8s Chain E (length=187) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAI
GDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGKAQKID
RMMEAFAQRYCLCNPGVFQSTDTCYVLSYSVIMLNTDLHNPNVRDKMGLE
RFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPED
Ligand information
Ligand IDSO3
InChIInChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2
InChIKeyLSNNMFCWUKXFEE-UHFFFAOYSA-L
SMILES
SoftwareSMILES
CACTVS 3.341[O-][S]([O-])=O
OpenEye OEToolkits 1.5.0[O-]S(=O)[O-]
ACDLabs 10.04[O-]S([O-])=O
FormulaO3 S
NameSULFITE ION
ChEMBL
DrugBank
ZINC
PDB chain1r8s Chain E Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1r8s Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
Resolution1.46 Å
Binding residue
(original residue number in PDB)		P154 G155 K156
Binding residue
(residue number reindexed from 1)		P93 G94 K95
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0032012 regulation of ARF protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1r8s, PDBe:1r8s, PDBj:1r8s
PDBsum1r8s
PubMed14654833
UniProtQ99418|CYH2_HUMAN Cytohesin-2 (Gene Name=CYTH2)

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