Structure of PDB 1p12 Chain E Binding Site BS01

Receptor Information
>1p12 Chain E (length=198) Species: 69 (Lysobacter enzymogenes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTVNATARIGGAV
VGTFAARVFPGNDRAWVSLTSAQTLLPRVANGSSFVTVRGSTEAAVGAAV
CRSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITS
AGQAQGVMSGGNVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG
Ligand information
Receptor-Ligand Complex Structure
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PDB1p12 Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S40 L41 C42 H57 Y171 M192 G193 S195 S214 G215 G216
Binding residue
(residue number reindexed from 1)		S15 L16 C17 H36 Y123 M138 G141 S143 S159 G160 G161
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 G193 S195 S214
Catalytic site (residue number reindexed from 1) H36 D63 G141 S143 S159
Enzyme Commision number 3.4.21.12: alpha-lytic endopeptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1p12, PDBe:1p12, PDBj:1p12
PDBsum1p12
PubMed1998685
UniProtP00778|PRLA_LYSEN Alpha-lytic protease (Gene Name=alpha-LP)

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