Structure of PDB 1k7l Chain E Binding Site BS01

Receptor Information
>1k7l Chain E (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY
Ligand information
Receptor-Ligand Complex Structure
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PDB1k7l Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Resolution2.5 Å
Binding residue
(original residue number in PDB)
K292 Q305 V306 K310 P458 L459 E462
Binding residue
(residue number reindexed from 1)
K91 Q104 V105 K109 P257 L258 E261
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1k7l, PDBe:1k7l, PDBj:1k7l
PDBsum1k7l
PubMed11698662
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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