Structure of PDB 1k7l Chain E Binding Site BS01
Receptor Information
>1k7l Chain E (length=267) Species:
9606
(Homo sapiens) [
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DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY
Ligand information
>1k7l Chain F (length=13) Species:
9606
(Homo sapiens) [
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ERHKILHRLLQEG
Receptor-Ligand Complex Structure
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PDB
1k7l
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
K292 Q305 V306 K310 P458 L459 E462
Binding residue
(residue number reindexed from 1)
K91 Q104 V105 K109 P257 L258 E261
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0004879
nuclear receptor activity
Biological Process
GO:0006355
regulation of DNA-templated transcription
Cellular Component
GO:0005634
nucleus
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Cellular Component
External links
PDB
RCSB:1k7l
,
PDBe:1k7l
,
PDBj:1k7l
PDBsum
1k7l
PubMed
11698662
UniProt
Q07869
|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)
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