Structure of PDB 1hef Chain E Binding Site BS01

Receptor Information

>1hef Chain E (length=99) Species: 11676 (Human immunodeficiency virus 1)

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEENSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

Ligand information

>1hef Chain I (length=5)

AAGVV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1hef The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): R8 D25 G27 A28 D29 G48 G49 V82
• Binding residue (residue number reindexed from 1): R8 D25 G27 A28 D29 G48 G49 V82

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1hef, PDBe:1hef, PDBj:1hef
• PDBsum: 1hef
• PubMed: 1429626
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)